Development of neural stem cells in the adult brain adult neurogenesis recapitulates the complete process of neuronal development in embryonic stages and we now know a great deal about each of developmental milestones reviewed by duan et al 2008the rapid progress can be largely attributed to introducing brdu kuhn et al 1996 and retroviral van praag et al 2002 methods for birth . Adult neurogenesis recapitulates the complete process of neuronal development in the mature cns environment 34advances in methodologies to detect new neurons have greatly facilitated the characterization of the basic process of adult neurogenesis and its dynamic regulation by a variety of physiological pathological and pharmacological stimuli 34. Adult neurogenesis the generation of new neurons in the adult brain is one of the most exciting fields of inquiry in the neurosciences most people believed it to be impossible until quite recently. Neural stem cells nscs are self renewing multipotent cells that generate the neurons and glia of the nervous system of all animals during embryonic developmentsome neural stem cells persist in the adult vertebrate brain and continue to produce neurons throughout life stem cells are characterized by their capacity to differentiate into multiple cell types. The mechanical problem of accommodating the dividing neurons has been overcome by the discovery that neural stem cells exist throughout life in the adult brain and can renew and give rise to new neurons astrocytes and oligodendrocytes just as in the developing brain
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